MEK Inhibitor PD0325901

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Information
Drug Name
MEK Inhibitor PD0325901
Description
Entry(CIViC)
6
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
uveal melanoma DDX43 OVEREXPRESSION
( ENST00000370336.5 ) DDX43 OVEREXPRESSION
( ENST00000370336.5 ) 		D Predictive Supports Resistance Somatic 4 24899684 Detail
skin melanoma NF1 MUTATION NF1 MUTATION D Predictive Supports Sensitivity/Response Somatic 3 23171796 Detail
uveal melanoma GNA11 MUTATION GNA11 MUTATION D Predictive Supports Sensitivity/Response Somatic 3 24141786 Detail
uveal melanoma GNAQ MUTATION GNAQ MUTATION D Predictive Supports Sensitivity/Response Somatic 4 24141786 Detail
cancer HRAS MUTATION HRAS MUTATION D Predictive Supports Sensitivity/Response Somatic 3 26544513 Detail
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) 		D Predictive Does Not Support Resistance Somatic 3 24576830 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
MEK inhibitor-resistant (selumetinib, PD0325901, G... DDX43 DDX43 OVEREXPRESSION
( ENST00000370336.5 ) DDX43 OVEREXPRESSION
( ENST00000370336.5 ) 		Resitance or Non-Reponse true CIViC Evidence detail
Preclinical study of mouse melanoma both in-vitro ... NF1 NF1 MUTATION NF1 MUTATION Sensitivity true CIViC Evidence detail
Preclinical study in uveal melanoma. Increased PKC... GNA11 GNA11 MUTATION GNA11 MUTATION Sensitivity true CIViC Evidence detail
Preclinical study in uveal melanoma. Increased PKC... GNAQ GNAQ MUTATION GNAQ MUTATION Sensitivity true CIViC Evidence detail
A pre-clinical study in 10 solid cancer cell lines... HRAS HRAS MUTATION HRAS MUTATION Sensitivity true CIViC Evidence detail
In the setting of BRAF(V600E), NF1 loss resulted i... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) 		Resitance or Non-Reponse false CIViC Evidence detail